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KMID : 0358220060330010045
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Korean Journal of Fertility and Sterility
2006 Volume.33 No. 1 p.45 ~ p.52
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A Study of Altered IL-6 and TNF-alpha Expression in Peritoneal Fluid of Patients with Endometriosis
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Kang Jeong-Bae
Lee Young-Keong
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Abstract
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Objective: Our purpose was to investigate the relationship between the levels of IL-6 and tumor necrosis factor-α in the peritoneal fluid of women with and without endometriosis and infertile women. Methods: This study is prospective and case-control study in University hospital, enrolled thirty-four women with laparoscopic findings of minimal to severe endometriosis, and thirty-seven women with no visual evidence of pelvic endometriosis and with benign gynecologic disease. IL-6 and tumor necrosis factor-α levels in peritoneal fluid were determined using commercial ELISA. IL-6 and tumor necrosis factor-α concentrations were compared among women with and without endometriosis, and with infertile and fertile women, and then also compared according the revised American Fertility Society classification. Results: IL-6 and tumor necrosis factor-α concentrations were higher than in the peritoneal fluid of women with endometriosis than in matched normal controls. Cyclic variations in IL-6 concentrations were seen in peritoneal fluid from patients with endometriosis: the concentrations in the secretory phase were significantly higher than those in the proliferative phase. The concentrations were higher than among of infertile women than in fertile women. A significant correlation between IL-6 and tumor necrosis factor-α concentrations and endometriosis stage III and IV was noted. Conclusion: Increased levels of IL-6 and tumor necrosis factor-α in patients with endometriosis in the peritoneal fluid may be relate to the pathogenesis of endometriosis suggesting that partially contribute to the disturbed immune regulation observed in patients with endometriosis.
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KEYWORD
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Endometriosis, Interleukin-6, Tumor necrosis factor-alpha
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